Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. doi: 10.1016/j.bmcl.2009.05.097. Epub 2009 May 29.

Abstract

We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Amidohydrolases / chemistry*
  • Animals
  • Azetidines / chemical synthesis*
  • Azetidines / chemistry*
  • Azetidines / pharmacology
  • Catalysis
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Chemical
  • Piperidines / chemical synthesis*
  • Piperidines / pharmacology
  • Rats
  • Receptor, Cannabinoid, CB1 / chemistry
  • Stereoisomerism
  • Urea / chemistry*

Substances

  • Azetidines
  • Enzyme Inhibitors
  • Piperidines
  • Receptor, Cannabinoid, CB1
  • VER 156084
  • azetidine
  • Urea
  • Amidohydrolases
  • fatty-acid amide hydrolase